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Compounds represented by formula (I), wherein R2 is selected from the group consisting of II, (Ct.4)alkyl, halo, haloalkyl, OH, (C,)alkoxy, NlI(CMalkyl) or N(C4alkyl)2; R4 is II or Me; R5 is H or Me; R" is II, (C)alkyl, (C,.4)cycloalkyl and (Ci.4)alkyl-(Cj_cycloalkyl; A is a connecting chain of (Ci.i)alkyl; B is O or S; n is 0 or 1; wherein when n is 0: Ring C is 6- or 10-membered aryl or 5- or 6-membered heterocycle having from 1 to 4 heteroatoms selected from the group consisting of O, N, and S, said aryl and said heterocycle being optionally substituted; and R is CONR12RU ; CONHNR'4R15; NR16COR17; NR18SO2(C,.,i)alkyl; SO2NR19R20; or SO2R21; or when n is 1: Ring C is as defined above and E is a single bond or a connecting group; and Ring D is 6- or 10-membered aryl or 5- or fi-membered heterocycle having from 1 to 4 heteroatoms selected from the group consisting of O, N, and S, said aryl and said heterocycle being optionally substituted with from 1 to 5 substituents; or a salt or a prodrug thereof are provided as inhibitors of HTV reverse transcriptase.