BigPatents India

T'he invention relates to thienopyridazinones of formula (I): wherein: R' is C1-6 alkyl, C2.6 alkcnyl or C3.6 cycloalkyl which is optionally substituted by C1.6 alkyl, each of the above being optionally substituted by one or more halogen atoms; R2 is C16 alkyl; R3 is a group CO-G or SO2-G where G is a 5- or 6-membercd ring containing a nitrogen atom and a second heteroatom selected from oxygen and sulphur adjacent to the nitrogen, and optionally subÂstituted by up to 3 groups selected from hydroxyl and C1-4alky]; Q is CR5R6 where R5 and R6 are as defined in the specification; and R4 is a 5- to 10-mcm-bered mono- or bi-cyclic aromatic ring system, containing 0 to 4 heteroatoms independently selected from nitrogen, oxygen and sulphur, the ring system beÂing optionally substituted as described in the specification, and pharmaceulically acceptable salts and solvales thereof. Processes for their preparation, pharmaceuiical compositions containing them and their use in Iherapy, in particular in the modulation of autoimÂmune disease are also described.