SUBSTITUTED BETA-AMINO ACID INHIBITORS OF METHIONINE AMINOPEPTIDASE-2
Application IN/PCT/2000/00559/MUM published 2007-01-19, filed 2000-10-30
$FODVVRIVXEVWLWXWHG-amino acids are potent inhibitors of methionine aminopeptidase type 2 (MetAP2) and are thus useful in inhibiting angiogenesis and disease conditions which depend upon angiogenesis for their development such as diabetic retinopathy, tumor growth, and conditions of inflammation. Pharmaceutical compounds containing the compounds and methods of inhibiting methionine aminopeptidase-2, and angiogenesis are also disclosed.
Applicant
1)ABBOTT LABORATORIES
:100, ABBOTT PARK ROAD, ABBOTT PARK, ILLINOIS 600 64-6008 U.S.A.
Inventor
1)RICHARD CRAIG 2)JACK HENKIN 3)MEGUMI KAWAI 4)LINDA LYNCH LIJEWSKI 5)JYOTI PATEL 6)GEORGE S SHEPPARD 7)JIEYI WANG
International Info
Classification: C07C323/60, A61K31/16, C07D295/185
Publication Number: WO 99/57098
Application Date: 1999-04-30
Priority Information
09/071,714 U.S.A. 1998-05-01