TARGETED TUMOR THERAPY BY USE OF RECOMBINANT ADENOVIRUS VECTORS THAT SELECTIVELY REPLICATE IN HYPOXIC REGIONS OF TUMORS
Application 1197/DELNP/2005 published 2007-01-19, filed 2005-03-28
The presently claimed subject matter provides conditionally replication competent adenoviral vectors that confer selective cytotoxicity on cells expressing HIF-1 by infecting cells that allow HIF-1 inducible prompters present within the vectors to function. Also provided are compositions and host cells based upon the vectors, as well as methods of propagating and using the vectors. The presently claimed subject matter further provides a method of inhibiting tumor growth by co-infecting cells in a tumor with a conditionally replication competent adenovirus vector in conjunction With a replication deficient adenovirus vector.
Applicant
1)DUKE UNIVERSITY
:OFFICE OF SCIENCE AND TECHNOLOGY, P.O. BOX 90083, DURHAM, NC 27708
Inventor
1)LI, CHUAM-YUAN 2)HUANG, QUAN 3)DEWHIRST, MARK, W.
International Info
Classification: A61K 48/00
Publication Number: WO 2004/031357
Application Date: 2003-10-01
Priority Information
60/415,319 U.S.A. 2002-10-01