"FLUORESCENT SILICA-BASED NANOPARTICLES"
Application 2703/DELNP/2005 published 2007-01-19, filed 2005-06-20
The present invention provides nanoparticle compositions comprising, for example, a core comprising a fluorescent silane compound; and a silica shell on the core. Also provided are methods for the preparation of nanoparticle compositions including fluorescent nanoparticles, ligated-fluorescent nanoparticles, ligated-fluorescent nanoparticles having therapeutic agents, and ligated-fluorescent nanoparticles coupled or associated with an analyte. Also provided are methods: for the detection of the ligated-fluorescent nanoparticles; for associating the linked-fluorescent nanoparticles with a cellular component of interest and recording or monitoring the movement of the cellular component; for improving the therapeutic properties of the therapeutic agent by combining the therapeutic agent with linked-fluorescent nanoparticles and contacting or administering the combination to a cell or organism; for making and using the fluorescent nanoparticles in, for example, diagnostic agents for the detection of various analytes, and like applications.
Applicant
1)CORNELL RESEARCH FOUNDATION, INC
:20 THORNWOOD DRIVE, SUITE 105, ITHACA, NY 14850, USA U.S.A.
Inventor
1)WIESNER, ULRICH,B 2)OW, HOOISWENG
International Info
Classification: C12Q
Publication Number: WO 2004/063387
Application Date: 2003-11-26
Priority Information
10/306,614 U.S.A. 2002-11-26