BigPatents India

.Compounds which are l-(2'-aminoacyl)-2-cyanopyrrolidine derivatives according to general formula (1) are DP-IV inhibitors for treatment of impaired glucose tolerance or type 2 diabetes; wherein A is selected from groups (2,3 and 4); X is selected from aminoacyl groups corresponding to the natural amino acids, acyl groups R3CO, groups R4COOC(R5)(R6)OCO, methoxycar-bonyl, elhoxycarbonyl and benzyloxycarbonyl; R1 is selected from H, C|-C6 alkyl residues, (CH2)2NHW1, (CH2)2COW2, (CH2)cOW3, CH(Me)OW4, (CH2)d-C-W and (CH2)eSW6, where a is 2-5, b is 1-4, c is 1-2, d is 1-2, e is 1-3, W1 is COW6, CO2W6 or SO2W6, W2 is OH, NH2, OW6 or NHW6, W3 is H or W6, W4 is H or w6, W6 is H, OH or OMe, and W6 is C,-C5 alkyl, optionally substituted phenyl, optionally substituted heteroaryl or benzyl and R2 is selected from H and (CH2)c-CsHsN-Y, where n is 2-4 and Y is H, F, CI, NO2 or CN, orR1 and R2 together are-(CH2)p-where is 3 or 4; R3 is selected from H,C1-C6 alkyl and phenyl; R4 is selected from H. C1-C6 alkyl, benzyl and optionally subsdtued phenyl; R5 and R6 are each independently selected from H and C1-C6 alkyl or together are -(CH2) where m is 4-6; R7 is selected from pyridyl and optionally substituted phenyl; Rs is selected from H and C1-C3 alkyl and R9 is selected from H, C1-C6 alkyl, C1-C6 aikoxy and phenyl.