"1,2,4-OXADIAZOLES AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR-5"
Application 486/DELNP/2005 published 2007-01-19, filed 2005-02-08
The present invention relates to new compounds of formula (I), a process for their preparation and new intermediates prepared therein, pharmaceutical formulations containing said compounds and to the use of said compounds in therapy. In particular, there are compounds according to the present invention that are potent and selective for the mGluR Group I receptor and more particularly for mGluR5. Thus, it is expected that the compounds of the invention are well suited for the prevention and/or treatment of mGluR5 receptor-mediated disorders such as acute and chronic neurological and psychiatric disorders and chronic and acute pain disorders.
Applicant
1)ASTRAZENECA AB
:S151 85, SODERTALJE, SWEDEN. Sweden 2)NPS PHARMACEUTICALS, INC.
Inventor
1)WENSBO, DAVID 2)XIN, TAO 3)STEFANAC, TOMISLAV 4)ARORA, JALAJ 5)EDWARDS, LOUISE 6)ISAAC, METHVIN 7)SLASSI, ABDELMALIK 8)STORMANN, THOMAS M. 9)MCLEOD, DONALD A. 10)KERS, ANNIKA 11)MALMBERG, JOHAN 12)OSCARSSON, KARIN 13)GYBACK, HELENA 14)JOHANSSON, MARTIN 15)MINIDIS, ALEXANDER 16)WALDMAN, MAGNUS 17)YNGVE, ULRIKA 18)OSTERWALL, CHRISTOFFER
International Info
Classification: C07D 413/12
Publication Number: WO 2004/014881
Application Date: 2003-08-08
Priority Information
60/402,040 U.S.A. 2002-08-09