METHODS AND COMPOSITIONS FOR CONTROL OF BONE FORMATION VIA MODULATION OF SYMPATHETIC TONE
Application 1412/DELNP/2004 published 2007-02-09, filed 2004-05-26
This invention relates to methods for treatment, diagnosis and prevention of bone disease and comprises methods including measurement and modulation of sympathetic tone and leptin activity. Alteration of sympathetic tone in bone disease can be accomplished by decreasing or increasing leptin synthesis, leptin receptor synthesis, leptin binding to the leptin receptor, and leptin receptor activity. Alteration of sympathetic tone in bone disease can also be accomplished in the foregoing manner, in combination with traditional sympathetic nervous system agonists and/or antagonists, such as, but not limited to, a dopamine beta hydroxylase antagonist or a beta adrenergic antagonist for treatment or prevention of osteoporosis.
Applicant
1)BAYLOR COLLEGE OF MEDICINE
:TEXAS MIDICAL CENTER, ONE BAYLOR PLAZA,, HOUSETON, TX 77030, USA U.S.A.
Inventor
1)KARSENTY GERARD 2)TAKEDA SHU 3)ELEFTERIOU FLORET
International Info
Classification: A61K
Publication Number: WO 03/049673
Application Date: 2002-10-31
Priority Information
60/337,054 U.S.A. 2001-12-05