PROCESS FOR PREPARING WATER-SOLUBLE PHOSPHONOOXYMETHYL DERIVATIVES OF ALCOHOL AND PHENOL

Application 1670/DELNP/2004 published 2007-03-23, filed 2004-06-14
A process for making water-soluble phosphonooxymethyl ethers of hindered alcohol and phenol containing pharmaceuticals, such as camptothecin, propofol, etoposide, Vitamin E and Cyclosporin A. In particular, the process for preparing water-soluble phosphonooxymethyl derivatives comprises the steps of Formula (i) and Formula (ii); R-OH represents an alcohol- or phenol-containing drug, n represents an integer of 1 or 2, R1 is hydrogen, an alkali metal ion, or a pharmaceutically acceptable cation, and R2 is hydrogen, an alkali metal ion, or a pharmaceutically acceptable cation.

Applicant

1)GUILFORD PHARMACEUTICALS, INC.,
:6611 TRIBUTARY STREET, BALTIMORE, MD 21224, UNITED STATES OF AMERICA. U.S.A.

Inventor

1)GEORGE BONNEVILLE 2)GREG DELAHANTY 3)ANDREW J. WALZ No of Pages : 17 No of Claims : 25

International Info

Classification: A61K
Publication Number: WO 2003/059255 A3
Application Date: 2002-12-20

Priority Information

60/341,867 U.S.A. 2001-12-21