"INDOLE-2-CARBOXAMIDES AS FACTOR XA INHIBITORS”
Application 1102/CHENP/2004 published 2006-02-03, filed 2004-05-18
The present invention relates to compounds of the formula (I), in which R0; R1; R2; R3; R4; R5; R6; R7; Q; V, G and M have the meanings indicated in the claims. The compounds of the formula (I) are valuable pharmacologically active compounds. They exhibit a strong antithrombotic effect and are suitable, for example, for the therapy and prophylaxis of cardiovascular disorders like thromboembolic diseases or restenoses. They are reversible inhibitors of the blood clotting enzymes factor Xa (FXa) and/or factor VIIa (FVIIa), and can in general be applied in conditions in which an undesired activity of factor Xa and/or factor VIIa is present or for the cure or prevention of which an inhibition of factor Xa and/or factor VIIa is intended. The invention furthermore relates to processes for the preparation of compounds of the formula (I), their use, in particular as active ingredients in pharmaceuticals, and pharmaceutical preparations comprising them.
Applicant
AVENTIS PHARMA DEUTSCHLAND GMBH
Brüningstrasse 50, 65929 Frankfurt, DENMARK.
Inventor
International Info
Classification: C07D 413/14, 401/12, 401/14, 209/42, 403/12, 409/14, 417/14, A61K 31/405
Publication Number: PCT/EP02/12500
Priority Information
01127809.0 EUROPE. 2001-11-22