A NEW AND EFFICIENT PROCESS FOR THE PREPARATION OF LAMOTRIGINE AND RELATED 3,5-DIAMINO-6-SUBSTITUTED-1,2,4-TRIAZINES

Application 1892/DELNP/2004 published 2007-04-06, filed 2004-07-01
A process for the manufacture of 3,5-diamino-kgg6-substituted-1,2,4-triazines is disclosed which comprises the steps of: (a) reacting a compound of formula (II): with aminoguanidine salts, (b) dehydrating the compound obtained to form a compound of formula (IV), and (c) cyclization of the compound of formula (IV) into a 3,5-diamino-6-substituted-1,2,4-triazine compound of formula (I) or into a hydrated form thereof.

Applicant

1)APOTEX PHARMACHEM INC.
:34 SPALDING DRIVE, BRANTFORD, ONTARIO N3T 6B8, CANADA. Canada

Inventor

1)GUNTOORI, BHASKAR, REDDY 2)CHE, DAQING 3)MURTHY, KESHAVA, K.S. No of Pages : 15 No of Claims : 27

International Info

Classification: C07D 253/075
Publication Number: WO 03/078407
Application Date: 2002-12-18

Priority Information

2,366,521 Canada 2001-12-24