NEW CRYSTALLINE MODIFICATION OF 2-

Application 1754/CHENP/2005 published 2007-04-06, filed 2005-07-29
The present invention relates to a new crystalline modification of 2-(3,5-bis-trifluoromethyl-phenyl)-N-[6-(1,1-dioxo-1&lgr;6-thiomorpholin-4-yl)-4(4-fluoro-2-methyl-phenyl)-pyridin-3-yl]-N-methyl-isobutyramide characterized by the following X-ray diffraction pattern obtained with a CUK&agr; radiationat 2&thetas; (2Theta)= 4.5, 6.4, 7.5, 7.7, 8.0, 8.2, 10.0, 10.2, 10.9, 11.1, 12.9, 13.4, 14.0, 14.5, 15.1, 15.6, 16.2, 16.5, 17.3, 17.5, 18.0, 18.9, 19.3, 19.5, 19.9, 20.1, 20.6, 21.0, 21.4, 22.7, 23.1 and 23.6 and an infrared spectrum having sharp bands at 2925, 2845, 1637, 1604, 1484, 1395, 1375, 1285, 1230, 1172, 1125, 1082, 999, 943, 893, 863, 860, 782, 705, 684 cm-1, and wherein the extrapolated melting point (DSC) is 137.2°C.

Applicant

1) F. HOFFMANN-LA ROCHE AG
:Grenzacherstrasse 124, CH-4070 Basel. Switzerland

Inventor

1)HOFFMANN, Torsten 2)HOFFMANN-EMERY, Fabienne 3)NICK, Sonia 4)SCHWITTER, Urs 5)WALDMEIER, Pius No of Pages : 24 No of Claims : 7

International Info

Classification: A61K 31/54
Publication Number: WO/2004/067007
Application Date: 2004-01-23

Priority Information

03002134.9 EUROPEAN UNION 2003-01-31