NOVEL HETEROCYCLYL-SUBSTITUTED HYDROXY-6-PHENYLPHENANTHRIDINES AND THEIR USE AS PDE4 INHIBITORS
Application 1144/MUMNP/2006 published 2007-04-13, filed 2006-09-25
Compounds of formula (I) in which R1 is hydroxyl, 1-4C-alkoxy, 3-7C-cydoalkoxy, 3-7C-cydoalkylmethoxy, 2,2-difluoroethoxy, or completely or predominantly fluorine-substituted 1-4C-alkoxy, R2 is hydroxyl, 1-4C-aikoxy, 3-7C-cydoalkoxy, 3-7C-cydoalkylmethoxy, 2,2-difluoroethoxy, or completely or predominantly fluorine-substituted 1-4C-alkoxy, or in which R1 and R2 together are a 1-2C-alkylenedioxy group, R3 is hydrogen or 1-4C-alkyl, R31 is hydrogen or 1-4C-alkyl, either, in a first embodiment (embodiment a) according to the present invention, R4 is -O-R41, in which R41 is hydrogen, 1-4C-aikyl,1-4C-alkoxy-1-4C-alkyl, hydroxy-2-C-alkyl, 1-7C-alkylcarbonyl, or completely or predominantly fluorine-substituted 1-4C-alkyl, and R5 is hydrogen or 1-4C-alkyl, or, in a second embodiment (embodiment b) according to the present invention, R4 Is hydrogen or 1-4C-alkyl, and R5 is -O-R51, in which R51 Is hydrogen, 1-4C-alkyl, 1-4C-alkoxy-1-4C-alkyl, hydroxy-2-4C-alkyl. 1-7C-alkylcarbonyl, or completely or predominantly fluorine-substituted 1-4C-alkyl, R6 is hydrogen, halogen, 1-4C-alkyl or 1.4C-alkoxy, R7 is Het1, Het2, Hart, Het3 or Har2, In which.
Applicant
1)ALTANA PHARMA AG
:BYK-GULDEN-STRASSE 2, D-78467 KONSTRAZ, Germany
Inventor
1)SCHMIDT BEATE 2)FLOCKERZI DIETER 3)HATZELMANN ARMIN 4)ZITT CHRISTOF 5)BARSIG JOHANNES 6)MARX DEGENHARD 7)KLEY HANS-PETER 8)KAUTZ ULRICH No of Pages : 33 No of Claims : 17
International Info
Classification: C07D 221/12
Publication Number: WO 2005/090311A1
Application Date: 2005-03-03
Priority Information
04005005.6 EUROPEAN UNION 2004-03-03