"THERAPEUTIC USES OF CHEMOKINE VARIANTS"
Application 1755/DELNP/2006 published 2007-04-13, filed 2006-03-30
Variants of homodimer-forming chemokines, such as human CCL2, having a single amino acid substitution in the dimerization interface that alters the pattern of hydrogen bonds and acting as an obligate monomer, can antagonize natural chemokines and have anti-inflammatory activity in vivo. These variants can be used as active ingredient in pharmaceutical compositions for the treatment of inflammatory, autoimmune, or infectious diseases.
Applicant
1)APPLIED RESEARCH SYSTEMS ARS HOLDING N.V.
:PIETERMAAI 15, CURACAO, NETHERLANDS ANTILES Netherlands
Inventor
1)PROUDFOOT AMANDA 2)SHAW JEFFREY 3)JOHNSON ZOE No of Pages : 65 No of Claims : 23
International Info
Classification: A61K 38/19
Publication Number: WO 2005/037305
Application Date: 2004-10-18
Priority Information
03078308.8 EUROPEAN UNION 2003-10-16