"REGULATION OF FOOD INTAKE AND GLUCOSE PRODUCTION BY MODULATION OF LONG-CHAIN FATTY ACYL-CoA LAVELS IN THE HYPOTHALAMUS"
Application 3304/DELNP/2005 published 2007-04-13, filed 2005-07-26
Methods of reducing food intake and glucose production in a mamma], or restoring hepatic auto regulation are provided. The methods involve increasing long-chain fatty acyl-Co A (LC-CoA) levels in (he hypothalamus. or stimulating efferent fibers in the hepatic branch of the vagus nerve. Also provided are methods of increasing food intake and glucose production in a mammal. The methods involve decreasing long-chain fatty acyl-Co-A (LC-CoA) levels in the hypothalamus of the mammal.
Applicant
1)ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY,
:1300 MORRIS PARK AVENUE, BRONX, NY 10461, UNITED STATES OF AMERICA U.S.A.
Inventor
1)LUCIANO ROSSETTI, 2)SILVANA OBICI, No of Pages : 57 No of Claims : 82
International Info
Classification: A61K
Publication Number: WO 2004/071458
Application Date: 2004-02-12
Priority Information
60/447,138 U.S.A. 2003-02-13