SUBSTITUTED N-PHENYL 2-HYDROXY-2-METHYL-3,3,3-TRIFLUROPROPANAMIDE DERIVATIVES WHICH ELEVATE PYRUVATE DEHYDROGENASE ACTIVITY

Application 132/MUMNP/2004 published 2006-02-03, filed 2004-02-20
Compounds of formula (I) wherein R is methyl or mesyl; and pharmaceutically acceptable salts and in vivo hydrolysable esters thereof are described. Also described are processes for their preparation, pharmaceutical compositions containing it and their use in producing an elevation of PDH activity in a warm-blooded animal. Drawing Sheets. Total Pages:

Applicant

ASTRAZENECA AB
S-151 85 SODERTAIJE, SWEDEN

Inventor

ROGER JOHN BUTLIN

International Info

Classification: 1. A61K 31/18 2. A61K 31/165 3. C07D 295/12 4. C07D 295/22
Publication Number: WO 03/017995 A1
Application Date: 2002-08-21

Priority Information

0120471.8 GREAT BRITAIN 2001-08-23