"2-AMINOARYLOXAZOLE COMPOUNDS AS TYROSINE KINASE INHIBITORS"
Application 2206/DELNP/2006 published 2007-04-20, filed 2006-04-21
The present invention relates to novel compounds selected from 2-aminoaryloxazoles of formula I that selectively modulate, regulate, and/or inhibit signal transduction mediated by certain native and/or mutant tyrosine kinases implicated in a variety of human and animal diseases such as cell proliferative, metabolic, allergic, and degenerative disorders. More particularly, these compounds are potent and selective c-kit, bcr-abl, FGFR3 and/or Flt-3 inhibitors.
Applicant
1)AB SCIENCE
:3, Avenue George V, F-75008 Paris
Inventor
1)MOUSSY, Alain 2)WERMUTH, Camille 3)GRIERSON, David 4)BENJAHAD, Abdellah 5)CROISY, Martine 6)CIUFOLINI, Marco 7)GIETHLEN, Bruno No of Pages : 71 No of Claims : 22
International Info
Classification: C07D 263/48
Publication Number: WO 2005/040139
Application Date: 2004-10-22
Priority Information
60/513,214 U.S.A. 2003-10-23