"SPIRO-HYDANTOIN COMPOUNDS USEFUL AS ANTI-INFLAMMATORY AGENTS"
Application 871/DELNP/2004 published 2007-05-11, filed 2004-04-05
Compounds having the formula (I), and pharmaceutically-acceptable salts, hydrates, enantiomers, and diastereomers, and prodrugs thereof, are useful as inhibitors of LFA-1/ICAM and as anti-inflammatory agents, wherein L and K are O or S; Z is N or CR4b; Ar is an optionally-substituted aryl or heteroaryl; G is a linker attached to T or M or is absent; J, M and T are selected to define a three to six membered saturated or partially unsaturated non-aromatic ring; and R2,R4a, and R4C are as defined in the specification.
Applicant
1)BRISTOL-MYERS SQUIBB COMPANY
:P.O. BOX 4000, ROUTE 206 AND PROVINCE LINE RD., PRINCETON, NEW JERSEY 08543-4000, U.S.A. U.S.A.
Inventor
1)T.G.MURALI DHAR 2)DOMINIQUE POTIN 3)MAGAILI JEANNINE BLANDINE MAILLET 4)MICHELE LAUNAY 5)ERIC ANTOINE NICOLAI 6)EDWIN J. IWANOWICZ No of Pages : 203 No of Claims : 32
International Info
Classification: C07D 401/04
Publication Number: WO 03/029245
Application Date: 2002-09-30
Priority Information
60/326,361 U.S.A. 2001-10-01