BigPatents India

A process for preparing Cefdinir of Formula II comprising the steps of, reacting thiazolyl acetic acid of Formula III; wherein R represents acetyl or trityl, with bis(5-methyl-1 ,3,4-thiadiazol-2..i yl)disulfide of Formula IV, in the presence oftriphenyl phosphine and an organic base in a solvent to I Produce thioester derivative of thiazolyl acetic acid of formula I wherein R is defined above; (ii) acylating the compound of Formula V; wherein R I represents H or silyl group with thioester derivative of Formula I to produce protected Cefdinir of Formula VI, wherein R is defined above; deprotecting compound of Formula VI to produce Cefdinir of Formula II.