AKT PROTEIN KINASE INHIBITORS
Application 1651/KOLNP/2006 published 2007-05-11, filed 2006-06-14
The present invention provides compounds, including resolved enantiomers, diastereomers, solvates and pharmaceutically acceptable salts thereof, comprising the Formula: A-L-CR where CR is a cyclical core group, L is a linking group and A is as defined herein. Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.
Applicant
1)ARRAY BIOPHARMA INC.
:3200 WALNUT STREET, BOULDER, CO 80301 U.S.A.
Inventor
1)MITCHELL, IAN S. 2)SPENCER, KEITH, L. 3)STENGEL, PETER 4)HAN, YONGXIN 5)KALLAN, NICHOLAS C 6)MUNSON, MARK 7)VIGERS, GUY, P.A. 8)BLAKE, JAMES 9)PISCOPIO, ANTHONY 10)JOSEY, JOHN 11)MILLER, SCOTT 12)XIAO, DENGMING 13)XU, RIU 14)RAO, CHANG 15)WANG, BIN 16)BERNACKI, APRIL, L No of Pages : 234 No of Claims : 43
International Info
Classification: A61K
Publication Number: WO 2005/051304
Application Date: 2004-11-19
Priority Information
60/524,003 U.S.A. 2003-11-21