INTEGRASE FUSION PROTEINS AND THEIR USE WITH INTEGRATING GENE THERAPY
Application 3744/DELNP/2006 published 2007-06-22, filed 2006-06-29
In a method of targeting integration of a transgene comprising retrovirus-like DNA into a eukaryotic genome, the genome is cleared by an endonuclease and the transgene is introduced at the site of cleavage, wherein the endonuclease is specific to a site in an abundant rDNA locus and is fused to an integrase that mediates the introduction of the transgene. The fusion protein may be new.
Applicant
1)ARK THERAPEUTICS LTD.
:79 NEW CAVENDISH ROAD, LONDON, W1W 6XB, UK. U.K.
Inventor
1)AHLROTH, MERVI 2)SCHENKWEIN, DIANA 3)AIRENNE, KARI 4)YLA-HERTTUALA, SEPPO 5)LAITINEN, OLLI
International Info
Classification: C12N 15/867
Publication Number: WO 2005/068641
Application Date: 2005-01-14
Priority Information
0400814.0 U.K. 2004-01-14