"FLUORENE DERIVATIVES"
Application 1180/DELNP/2006 published 2007-07-13, filed 2006-03-06
This invention relates to a novel fluorene derivative having a characteristic structure in which guanidino group or the like functional group is linked to the fluorene structure via carbonyl group, or a salt thereof. The compound of the invention has an advantage in that it has high affinity for serotonin receptor subtypes, particularly for 5-HT2B receptor and 5-HT7 receptor, and shows excellent pharmacological effects in comparison with the conventional compounds which have only one of the antagonistic activities of 5-HT2B receptor and 5-HT7 receptor, this is useful as a prophylactic antimigraine agent having high safety and excellent effect.
Applicant
1)ASTELLAS PHARMA INC.
:3-11, NIHONBASHI-HONCHO 2-CHOME, CHUO-KU, TOKYO 103-8411, JAPAN. Japan
Inventor
1)HIROYOSHI YAMADA 2)HIROTSUNE ITAHANA 3)AYOKO MORITOMO 4)TAKAHO MATSUZAWA 5)KOICHIRO HARADA 6)JIRO FUJIYASU 7)YUJI KOGA 8)MAKOTO OKU 9)TOSHIO OKAZAKI 10)SHINOBU AKUZAWA 11)TOSHIHIRO WATANABE
International Info
Classification: C07C 279/22
Publication Number: WO 2005/080322
Application Date: 2005-02-17
Priority Information
2004-044122 Japan 2004-02-20