MODULATORS OF P-SELECTIN GLYCOPROTEIN LIGAND 1
Application 1217/DELNP/2006 published 2007-07-13, filed 2006-03-07
Multimeric compounds that bind to P-Selectin Glycoprotein 1 (PSGL-1) on the surface of T cells or natural killer (NK) cells can be used to induce T cell or NK cell depletion and/or to induce T cell or NK cell apoptosis. The multimeric compounds and methods of the invention can be used to control unwanted T cell-or NK cell-mediated immune responses in conditions such as inflammatory diseases, autoimmune diseases, transplant rejection, and allergic diseases.
Applicant
1)ABGENOMICS CORPORATION
:2F, NO. 32, LN. 358, JUIKUANG RD., NEIHU, TAIPEI, TAIWAN 114, R.O.C.
Inventor
1)LIN, RONG-HWA 2)CHANG, CHUNG, NAN
International Info
Classification: A61K 38/17
Publication Number: WO 2005/027831
Application Date: 2004-09-09
Priority Information
60/310,196 U.S.A. 2001-08-03