METHODS FOR IDENTIFYING A PATIENT AS A CANDIDATE FOR TREATMENT WITH A LONG ACTING BETA AGONIST AND FOR PREDICTING A PATIENT S RESPONSE TO LONG ACTING BETA 2 AGONIST THERAPY BY ANALYSING POLYMORPHISMS IN THE BETA 2 - ADRENERGIC RECEPTOR GENE

Application 2712/DELNP/2007 published 2007-07-13, filed 2007-04-11
The invention relates to a method for identifying a patient as a candidate for treatment with a long acting beta agonist comprises isolating a biological sample from a patient and identifying the presence or absence of at least one haplotype C in the beta2-adrenergic receptor gene. The presence of at least one haplotype C in a patient sample indicates that patient is a good candidate for treatment. For example, the patient may have a respiratory disease, preferably an obstructive airway disease, and most preferably, COPD or asthma. The invention also related to a method for predicting an asthma patient's response to long acting beta2 agonist therapy comprising detecting polymorphisms in the beta2 adrenergic receptor gene.

Applicant

1)ASTRAZENECA AB
:SE 151 85 SODERTALJE, SWEDEN Sweden

Inventor

1)HELEN JEAN AMBROSE 2)MITCHELL JOEL GOLDMAN

International Info

Classification: C12Q 1/68
Publication Number: WO 2006/031181
Application Date: 2005-09-12

Priority Information

0402198-6 Sweden 2004-09-13