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Compounds of formula (1) wherein X is a fluorine or a chlorine atom; the methyl groups located at the 2- and 5-position of the piperazine ring are in transconfiguration to each other; Y is NH or O; R1 is selected from hydrogen, chloro, bromo, nitro, methyl or triflouromethyl; R2 is selected from hydrogen, halo, methyl, triflouromethyl, methoxy or triflouromethoxy; or a pharmaceutically acceptable salt or solvate thereof, pharmaceutical compositions containing them and their use in therapy for treating inflammatory, autoimmune, proliferative or hyperproliferative diseases.