BigPatents India

PROCESS FOR THE PREPARATION OF AMINOPYRIMIDINES Abstract The present invention provides a process for the preparation of a compound of formula (I); wherein X is halogen; Y is ZR1; Z is oxygen or sulphur; and R1 is C ^ alkyl, Ci-e haloalkyl or 3-7 cloalkyl; the process comprising either: hydrogenating a compound of formula (II); with a suitable transition metal catalyst in a Ci-e aliphatic alcohol, an ether, an hydrocarbon as solvent; or, b) conducting a one-pot hydrogenation of a compound of formula (III): wherein R2 is phenyl optionally substituted by chlpro.Ci-e alkyl, Ci-e alkoxy or (C-i-e alkyl)2N; firstly at about 20°C to form a compound of formula (IV): and then at about 40°C; both steps (I) and (ii) being carried out in the presence of a suitable catalyst and in the presence of a suitable solvent.