BigPatents India

Compound of formula (I) or a pharmaceutically-acceptable salt thereof, formula (I) wherein Ar is optionally substi-tuted phenyl; R1 is selected from: formula a) or b) (wherein is a single or double bond); R5, R6, R7 and R8 are for example hydrogen or alkyl; R4 is selected from hydrogen, (3-4C)cycloalkyl and optionally substituted (1 -4C)alkyl; R10 is for example selected from hydrogen, (l-4C)alkyl, (3-6C)cycloalkyl(l-4C)alkyl, hydroxy(l-4C)alkyl, (l-4C)alkoxy, aryl(l-4C)alkyl; Y is carbon and Ring A is optionally substituted phenylene; or each Y may independently be carbon or nitrogen and Ring A is optionally substituted 5- or 6-membered, heteroarylene ring, R11 is selected from hydrogen and optionally substituted phenyl; p is independently at each occur-rence 0, 1 or 2; are described. Processes for making such compounds and their use as DPP-IV inhibitors in the treatment of diabetes are also described.