BUTYLPHTHALIDE SELF-EMULSIFYING DRUG DELIVERY SYSTEM, ITS PREPARATION METHOD AND APPLICATION
Application 1030/KOLNP/2007 published 2007-07-13, filed 2007-03-23
The present invention relates to a novel drug delivery and release system, i.e. Self- emulsifying Drug Delivery System (SEDDS), of butylphthalide, to a preparation process thereof, and to a use thereof in a pharmaceutical formulation. The drug delivery system comprises as essential ingredients 1% to 65% of butylphthalide and 10% to 65% of an emulsifying agent, together with various excipients as required depending on the desired dosage forms. The present invention significantly increases the contact area between butylphthalide and the mucous membrane of the gastrointestinal tract, and therefore improves the absorptivity of the drug.
Applicant
1) SHIJIAZHUANG PHARMA GROUP ZHONGQI PHARMACEUT ICAL TECHNOLOGY
NO. 276 ZHONGSHAN WEST ROAD, SHIJIAZHUANG, HEBEI PROVINCE 050051, P.R. CHINA
Inventor
1)LIU, ZHENTAO 2)YANG, LIYING 3)YANG, HANYU 4)GAO, YUQING 5)SHEN, DONGMIN 6)GUO, WENMIN 7)FENG, XIAOLONG 8)ZHENG, JIA
International Info
Classification: A61K 9/107, 9/48
Publication Number: WO 2006/021160
Application Date: 2005-08-26
Priority Information
200410075068.2 China 2004-08-27