AN IMPROVED PROCESS FOR THE PREPARATION OF ESCIT ALOPRAM
Application 1014/CHE/2005 published 2007-07-20, filed 2005-07-27
The present invention relates to an improved process for the preparation of Escitalopram of the Formula I, which consists of sequential two Grignard reactions on 5-cyanophthalide, isolation of Diol compound of Formula VI as an oxalate salt, resolution of Diol compound and cyclization of resolved compound of Formula VII. The present invention provides a process to obtain pure Diol compound by preparing its Oxalate salt, which is useful for resolution of enantiomers.
Applicant
1)AUROBINDO PHARMA LIMITED
:AUROBINDO PHARMA LIMITED PLOT NO.2, MAITRIVIHAR COMPLEX, AMEERPET, HYDERABAD-500 038
Inventor
1)VIPIN KUMAR KAUSHIK 2)MOHAMMED UMAR KHAN 3)MEENAKSHISUNDERAM SIVAKUMARAN
International Info
Classification: A61K 31/343