BENZIMIDAZOLE ACETIC ACIDS EXHIBITING CRTH2 RECEPTOR ANTAGONISM AND USES THEREOF.
Application 1397/KOLNP/2007 published 2007-07-20, filed 2007-04-19
The invention relates to benzimidazole acetic add compounds which function as antagonists of the Chemoattractant Receptor-homologous molecule expressed on T-Helper type 2 cells (CRTH2) receptor. The invention also relates to the use of these compounds to inhibit the binding of prostaglandin D2 and its metabolites or certain thromboxane metabolites to the CRTH2 recptor and to treat disorders responsive to such inhibition.
Applicant
1)ATHERSYS, INC.
:3201, CARNEGIE AVENUE, CLEVELAND, OHIO 44115-2634, UNITED STATES OF AMERICA U.S.A.
Inventor
1)BENNANI, YOUSSEF L. 2)TUMEY, L. NATHAN 3)GLEASON, ELIZABETH ANN 4)ROBARGE, MICHAEL JOSEPH
International Info
Classification: C07D 235/06
Publication Number: WO 2006/034418
Application Date: 2005-09-21
Priority Information
60/611,296 U.S.A. 2004-09-21