LIPOSOME FORMULATION OF PEPTIDE BORONIC ACIDS COMPOUNDS
Application 1601/KOLNP/2007 published 2007-07-27, filed 2007-05-04
A liposome composition comprised of liposomes having a peptide boronic acid proteasome inhibitor compound entrapped in the liposome is described. The boronic acid compound is entrapped in the liposome in the form of a boronate ester, subsequent to interaction with a liposome-entrapped polyol. In one embodiment, the liposomes have an outer coating of hydrophilic polymer chains and are used to treat a malignancy in a subject.
Applicant
1)ALZA CORPORATION
:1900 CHARLESTON ROAD MOUNTAIN VIEW, CA 94043 U.S.A.
Inventor
1)SAMUEL ZALIPSKY 2)FRANCIS MARTIN
International Info
Classification: A61K 9/127
Publication Number: WO 2006/052734
Application Date: 2005-11-04
Priority Information
60/625,216 U.S.A. 2004-11-05