FUSED PYRMIDINE DERIVATIVES AND COMPOSITIONS THEREOF AS CXCR3 RECEPTOR MODULATORS, USEFUL IN PRVENTION AND TREATMENT OF INFLAMMATORY AND IMMUNOREGULATORY DISORDERS AND DISEASES
Application 375/CHENP/2007 published 2007-08-24, filed 2007-01-29
Compounds are provided having the formula: wherein variables R\ R1. R". R\ R\ A1. A4. L. Q. X and subscript n as described herein. The subject compounds are useful for treatment of inflammatory and immune conditions and diseases. Compositions and methods of treatment using the subject compounds are also provided. For example, the subject methods are useful for treatment of inflammatory and immune disorders and disease such as multiple sclerosis. rheumatoid arthritis, psoriasis, and inflammatory bowel disease.
Applicant
1)AMGEN INC.
:ONE AMGEN CENTER DRIVE, THOUSAND OAKS, CALIFORNIA 91320-1799, USA U.S.A.
Inventor
1)FU, ZICE 2)JOHNSON, MICHAEL, G 3)LI, AN-RONG 4)MARCUS, ANDREW, P 5)MEDINA, JULIO, C 6)BERGERON, PHILIPPE 7)CHEN, XIAOQI 8)DEIGNAN, JEFFREY 9)DU, XIAOHUI 10)DUQUETTE, JASON, A 11)GUSTIN, DARIN 12)MIHALIC, JEFFREY, T
International Info
Classification: C07D 471/04
Publication Number: WO 2006/004915 A1
Application Date: 2005-06-28
Priority Information
60/583,901 U.S.A. 2004-06-28