A STABILIZED PHARMACEUTICAL TABLETS CONTAINING TIBOLONE AND A COATING
Application 937/CHENP/2005 published 2007-08-24, filed 2005-05-16
The present invention relates to a stabilized pharmaceutical tablet comprising an amount of from 0.1 to 10% by weight of tibolone provided with a coating, such as a film coating, a sugar coating, a sugar film coating or a "wrap" coating. The invention further relates to the use of a coating for stabilizing a pharmaceutical tablet comprising tibolone. Preferably, the coating is a sugar coating or a sugar film coating. Preferably, the sugar comprises sucrose. These tablets were shown to have a lower amount of OM38, i.e. an isomerization degradation product of tibolone, after storage as compared to uncoated tibolone tablets.
Applicant
1)AKZO NOBEL N.V
:Velperweg 76, NL-6824 BM Arnhem Netherlands
Inventor
1)DE HAAN, Pieter 2)VAN LARE, Cornelis, Elisabeth, Johannus
International Info
Classification: A61K 9/36
Publication Number: WO 2004/045587 A1
Application Date: 2003-11-13
Priority Information
02079920.1 EUROPEAN UNION 2002-11-20