"METHODS FOR REFOLDING OF RECOMBINANT ANTIBODIES"
Application 3778/DELNP/2007 published 2007-08-24, filed 2007-05-21
The present invention is generally directed to methods of producing increase in the enrichment or recovery of preferred forms of IgG proteins. More particularly, the invention relates to subjecting preparations of such recombinant IgG proteins with a reduction/oxidation coupling reagent and optionally a chaotropic agent.
Applicant
1)AMGEN INC.
:ONE AMGEN CENTER DRIVE, THOUSAND OAK, CA 91320-1799 USA. U.S.A.
Inventor
1)DILLON THOMAS 2)REHDER DOUGLAS 3)BONDARENKO PAVEL 4)RICCI MARGARET 5)GADGIL HIMANSHU S. 6)BANKS DOUGLAS 7)ZHOU JOE 8)LU YUEFENG
International Info
Classification: C12P 21/06
Publication Number: WO 2006/047340
Application Date: 2005-10-21
Priority Information
60/621,295 U.S.A. 2004-10-22