COFORMULATION METHODS AND THEIR PRODUCTS
Application IN/PCT/2002/00207 published 2006-03-03, filed 2002-02-08
A coformulation of an active (preferably pharmaceutically active, for instance a COX-2 enzyme inhibitor) substance and an oligomeric or polymeric excipient, containing at least 10 % of the active, between 80 and 100 % of which is amorphous. The amorphous phase is stable, with respect to the crystalline phase(s), for at least three months after its preparation when stored at between O and 10 °C. The invention also provides processes, preferably involving SEDSTM particle formation, for preparing such a coformulation. (FIG. - 1)
Applicant
BRADFORD PARTICLE DESIGN LIMITED & BRISTOL-MYERS SQUIBB COMPANY
UNIT 69 LISTERHILLS SCIENCE PARK CAMPUS ROAD,BRADFORD BD7 1HR UK & P.O. BOX 4000 PRINCETOWN NJ 08543-4000 USA
Inventor
YORK PETER WILKINS SIMON ANTHONY STOREY RICHARD ANTHONTY WALKER STEPHEN ERNEST HARLAND RONALD SCOTT
International Info
Classification: A61K 9/00
Publication Number: WO 01/15664 A2
Application Date: 2000-08-31
Priority Information
9920558.5 GB 1999-08-31