MODIFIED TRANSFERRIN-ANTIBODY FUSION PROTEINS
Application 351/KOLNP/2005 published 2006-03-03, filed 2005-03-07
Modified fusion proteins of transferrin and therapeutic proteins or peptides, preferably antibody variable regions, with increased serum half-life or serum stability are disclosed. Preferred fusion proteins include those modified so that the transferrin moiety exhibits no or reduced glycosylation, binding to iron and/or binding to the transferrin receptor. (FIG. - nil)
Applicant
BIOREXIS PHARMACEUTICAL CORPORATION
3400 HORIZON DRIVE KING OF PRUSSIA PHILADELPHIA ,PA 19406-2675 USA
Inventor
1. SADEGHI HOMAYOUN 2. PRIOR CHRISTOPHER P 3. TURNER ANDREW J
International Info
Classification: C07H 21/04,C12N 15/63,15/65,15/86,A01K 67/00,C07K 16/00 A61K 39/395
Publication Number: WO 04/020404 A3
Application Date: 2003-08-28
Priority Information
60/406,977 US 2002-08-30