“ ENZYMATIC RESOLUTION OF T-BUTYL TAXANE DERIVATIVES“
Application 419/DELNP/2004 published 2006-03-10, filed 2004-02-23
A method for the resolution of a mixture of the cis or trans enantiomers of a compound of the formula [insert chemical structure] wherein R1 is -O-C(O)alkyl, -O-C(O)aryl or -O-C(O)cycloalkyl by contacting the mixture with a carboxylic ester hydrolase enzyme which catalyzes the stereoselective hydrolysis of the mixture and the use of such enantiomers to produce antitumor compounds which are especially suitable for oral administration.
Applicant
BRISTOL-MYERS SQUIBB COMPANY
P.O. Box 4000, Route 206 and Province Line Rd, Princeton, New Jersey 08543-4000, USA
Inventor
RAMESH N. PATEL
International Info
Classification: C12P
Publication Number: WO 03/016543
Application Date: 2002-08-21
Priority Information
60/313,757 U.S.A. 2001-08-21