ANTI-PROTOZOAL VACCINE

Application 1264/KOLNP/2004 published 2006-11-03, filed 2004-08-30
Immunotherapy of protozoal diseases is provided by use of hypoxanthine guanine xanthine phosphoribosyl transferase protein, or peptide fragments thereof, as an immunogen in vaccines effective against protozoal diseases such as malaria and babesiosis. In particular, immunization with hypoxanthine guanine xanthine phosphoribosyl transferase or peptide fragments thereof, induces T cell immunity to blood stage malaria. In particular embodiments, the invention provides protein and DNA malaria vaccines and methods of prophylactic and therapeutic immunization that elicit T cellíPHGLDWHGLPPXQHUHVSRQVHVEURDGO\DSSOLFDEOHWRSURWR]RDOGLVHDVHVincluding malaria. (FIG.Nil)

Applicant

THE COUNCIL OF THE QUEENSLAND INSITITUTE OF MEDICAL RESEARCH.,
THE BANCROFT CENTRE, 300 HERSTON ROAD, AUSTRALIA.

Inventor

MAKOBONGO MORRIS RIDING GEORGE ALFRED WILLADSEN PETER GOOD MICHAEL

International Info

Classification: C07H 21/02, 21/04, C12N 5/06, 5/08, C07K 14/445, 14/44, 16/20, A61K 31/7105, 31/711, 38/10, 38/45, 39/015, 39/018, A61P 33/06
Publication Number: WO 03/074543
Application Date: 2003-02-28

Priority Information

PS 0845 AUSTRALIA 2002-03-01