"ENZYMATIC RESOLUTION OF T-BUTYL TAXANE DERIVATIVES'

Application 419/DELNP/2004 published 2007-09-28, filed 2004-02-23
A method for the resolution of a mixture of the cis or trans enan- tiomers of a compound of the formula [insert chemical structure] wherein RI -O-C(O)aIkyl, -O-C(O)aryl or -O-C(O)cycloalkyl by contacting the mixture with a carboxyli cester hydrolase enzyme which catalyzes the stereoselective hydrolysis of the mixture and the use of such enantiomers to produce antitumor compounds which are especially suitable for oral administration.

Applicant

1)BRISTOL-MYERS SQUIBB COMPANY
:P.O. BOX 4000, ROUTE 206 AND PROVINCE LINE RD, PRINCETON, NEW JERSEY 08543-4000, U.S.A. U.S.A.

Inventor

1)RAMESH N. PATEL

International Info

Classification: C12P
Publication Number: WO 03/016543
Application Date: 2002-08-21

Priority Information

60/313,757 U.S.A. 2001-08-21