"ARYL-SUBSTITUTED PYRAZOLE COMPOUNDS USEFUL AS KINASE INHIBITORS"
Application 4728/DELNP/2005 published 2007-09-28, filed 2005-10-18
The present invention relates to compounds having the formula (I), and phar-maceutically-acceptable salts, prodrugs, solvates, isomers, and/or hydrates thereof, wherein Q is an optionally-substituted phenyl, pyridyl, pyridazinyl, pyrimidinyl, or pyrazinyl ring; R2 is alkyl or an amino group as defined herein; and Z is optionally-substituted oxadiazolyl or -C(=O)NR6, wherein R6 is lower alkyl or cyclopropyl. The compounds are surprisingly advantageous in preparing medicaments for treating p38 kinase related conditions and/or in preparing medicaments for use in treating inflammatory disorders or conditions in a patient.
Applicant
1)BRISTOL-MYERS SQUIBB COMPANY
:P.O. BOX 4000, 206 AND PROVINCELINE ROAD, PRINCETON, NEW JERSEY 08543-4000, U.S.A. U.S.A.
Inventor
1)ALARIC DYCKMAN 2)JAGABANDHU DAS 3)KATERINA LEFTHERIS 4)CHUNJIAN LIU 5)RULIN ZHAO 6)BANG-CHI CHEN 7)STEPHEN T. WROBLESKI
International Info
Classification: C07D 231/18
Publication Number: WO 2004/099156
Application Date: 2004-05-03
Priority Information
60/467,029 U.S.A. 2003-05-01