: INHIBITORS OF MACROPHAGE MIGRATION INHIBITORY FACTOR AND METHODS FOR IDENTIFYING THE SAME

Application 1360/KOLNP/2003 published 2006-03-24, filed 2003-10-22
Inhibitors of MIF are provided which have utility in the treatment of a variety of disorders, including the treatment of pathological conditions associated with MIF activity. The inhibitors of MIF have the following structures: (Ia) (Ib) including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein n, R1, R2, R3, R4, X, Y and Z are as defined herein. Compositions containing an inhibitor of MIF in combination with a pharmaceutically acceptable carrier are also provided, as well as methods for use of the same. (FIG. 1)

Applicant

AVANIR PHARMACEUTICALS,
11388 Sorrento Valley Road, Suite 200, San Diego, CA 92121,U.S.A.

Inventor

1. GAETA, Federico, C.A. 2. BAIRD, Andrew 3. ANCHIN, Jerry 4. YING, Wenbin, 5. FLORKIEWICZ, Robert 6. SIRCAR, Jagadish 7. KUMAR K.C., Sunil :YES

International Info

Classification: A61K 31/47
Publication Number: WO 02/094203
Application Date: 2002-05-24

Priority Information

60/293,642 U.S.A. 2001-05-24