: HUMAN ANTI-NGF NEUTRALIZING ANTIBODIES AS SELECTIVE NGF PATHWAY INHIBITORS
Application 322/KOLNP/2006 published 2007-05-25, filed 2006-02-14
This invention provides antibodies that interact with or bind to human nerve growth factor (NGF) and neutralize the function of NGF thereby. The invention also provides pharmaceutical compositions of said antibodies and methods for neutralizing NGF function, and particularly for treating NGF-related disorders (e.g., chronic pain) by administering a pharmaceutically effective amount of anti-NGF antibodies. Methods of detecting the amount of NGF in a sample using anti-NGF antibodies are also provided. (FIG. 5)
Applicant
AMGEN INC.
ONE AMGEN CENTER DRIVE, THOUSAND OAKS, CALIFORNIA 91320, U.S.A
Inventor
1. WILD KENNETH D, JR. 2. TREANOR JAMES JS 3. HUANG HAICHUN 4. INOUE HEATHER 5. ZHANG TIE J 6. MARTIN FRANK Filed U/S 5(2) before The Patents
International Info
Classification: A61K 39/395, C07K 16/22, G01N 33/53
Publication Number: WO 2005/019266 A3
Application Date: 2004-07-15
Priority Information
60/487,431 U.S.A 2003-07-15