ANTIBODIES TO MADCAM.
Application 2237/KOLNP/2006 published 2007-05-25, filed 2006-08-07
The present invention relates to antibodies including human antibodies and antigen-binding portions thereof that specifically bind to MAdCAM, preferably human MAdCAM and that function to inhibit MAdCAM The invention also relates to human anti-MAdCAM antibodies and antigen-binding portions thereof The invention also relates to antibodies that are chimeric, bispecific, derivatized, single chain antibodies or portions of fusion proteins The invention also relates to isolated heavy and light chain immunoglobulins derived from human anti-MAdCAM antibodies and nucleic acid molecules encoding such immunoglobulins The present invention also relates to methods of making human anti-MAdCAM antibodies, compositions comprising these antibodies and methods of using the antibodies and compositions for diagnosis and treatment The invention also provides gene therapy methods using nucleic acid molecules encoding the heavy and/or light lmmunoglobulin molecules that comprise the human anti-MAdCAM antibodies. The invention also relates to transgenic animals or plants composing nucleic acid molecules of the invention
Applicant
1)AMGEN FREMONT INC.
:6701, KAISER DRIVE, FREMONT, CALIFORNIA 94555 U.S.A. 2)PFIZER INC.
Inventor
1)PULLEN, NICHOLAS 2)MOLLOY, ELIZABETH 3)KELLERMANN, SIRID-AIMEE 4)GREEN, LARRY L. 5)HAAK-FRENDSCHO, MARY No of Pages : 249 No of Claims : 53
International Info
Classification: C07K 16/28
Publication Number: WO 2005/067620
Application Date: 2005-01-07
Priority Information
60/535,490 U.S.A. 2004-01-09