RESIDUAL SOLVENT EXTRACTION METHOD AND MICROPARTICLES PRODUCED THEREBY
Application 129/KOLNP/2004 published 2006-04-07, filed 2004-02-04
Methods for preparing microparticles having reduced residual solvent levels, Microparticles are contacted with a non-aqueous washing system to reduce the level of residual solvent in the microparticles, Preferred non-aqueous washing systems include 100% ethanol and a blend of ethanol and heptane. A solvent blend of a hardening solvent and a washing solvent can be used to harden and wash microparticles in a single step, thereby eliminating the need for a post-hardening wash step. (FIG. 1)
Applicant
ALKERMES CONTROLLED THERAPEUTICS INC. II
88 Sidney Street, Cambridge, MA 02139, USA.
Inventor
RICKEY, Michael, E RAMSTACK, J., Michael KUMAR, Rajesh
International Info
Classification: A61K 9/16, B01J 13/20
Publication Number: WO 03/020245
Application Date: 2002-08-26
Priority Information
09/942,631 US 2001-08-31