THERAPEUTICALLY USEFUL TRIETHYLENEGLYCOL CHOLESTERYL OLIGONUCLEOTIDES
Application 350/KOLNP/2004 published 2006-04-07, filed 2004-03-15
The present invention provides a composition comprising a 5'-OR, 3'- TEG cholesteryl synthetic sequence wherein the sequence is SEQ ID NO:5, SEQ ID NO:6, SEQ ID NO:7, SEQ ID NO:8, and a pharmaceutically acceptable carrier. The present invention also provides methods of using of this composition in preparation of medicaments, and methods of using this composition for induction of a response in a cell, including but not limited to inhibition of cellular proliferation, induction of cell cycle arrest, induction of caspase activation, cleavage of poly(ADP-ribose) polymerase, induction of apoptosis or modulation of extracellular matrix-cell interactions, or combinations thereof, in cancer cells and/or synovial cells. (FIG. NIL)
Applicant
BIONICHE LIFE SCIENCES INC. & HERRERA-GAYOL, Andrea, Cristina.
231 Dundas Street E., Belleville, Ontario K8N 1EZ & 27 de Casson, Westmount, Quebec H3Y 2G9, CANADA.
Inventor
1.HERRERA-GAYOL, Andrea, Cristina 2.PHILLIPS, Nigel, C. 3.FILION, Mario, C.
International Info
Classification: A61K 47/48, 31/7088, C07H 21/04, A61P 35/00, 19/02
Publication Number: WO 03/028764
Application Date: 2002-10-03
Priority Information
60/326,884 US 2001-10-03