MODULATORS OF PEROXISOME PROLIFERATOR ACTIVATED RECEPTORS
Application 1456/KOLNP/2003 published 2006-04-14, filed 2003-11-10
Disclosed is a compound represented by Structural Formula (I): Ar is a substituted or unsubstituted aromatic group. Q is a covalent bond, -CH2-or-CH2CH2-; W is a substituted or unsubstituted alkylene or a substituted or unsubstituted heteroalkylene linking group from two to ten atoms in length, preferably from two to seven atoms in length. Phenyl Ring A is optionally substituted with up to four substituents in addition to R1 and W. R1 is (CH2)n-CH(OR2)-(CH2)mE, -(CH)=C(OR2)-(CH2)mE, -(CH2)n-CH(Y)-(CH2)mE or (CH)=C(Y)-(CH2)mE; wherein E is COOR3, C1-C3 alkylnitrile, carboxamide, sulfonamide, acylsulfonamide or tetrazole and wherein sulfonamide, acylsulfonamide and tetrazole are optionally substituted with one or more substituents independently selected from: C1-C6 alkyl, haloalkyl and aryl-C0-4-alkyl; R2 is H, an aliphatic group, a substituted aliphatic group, haloalkyl, an aromatic group, a substituted aromatic group, -COR4, -COOR4, -CONR5R6, -C(S)R4, -C(S)OR4 or C(S)NR5R6. R3 is H, an aliphatic group, a substituted aliphatic group, an aromatic group or a substituted aromatic group. Y is O-, CH2-, -CH2CH2- or CH=CH- and is bonded to a carbon atom in Phenyl Ring A that is ortho to R1. R4-R6 are independently H, an aliphatic group, a substituted aliphatic group, an aromatic group or a substituted aromatic group. n and m are independently 0, 1 or 2. (FIG.nil )
Applicant
(1) ELI LILLY AND COMPANY (2) LIGAND PHARMACEUTICALS INC.
(1) LILLY CORPORATE CENTER INDIANAPOLIS, INDIANA 46285, U.S.A (2) 10275 SCIENCE CENTER DRIVE, SAN DIEGO, CALIFORNIA 92121, U.S.A
Inventor
(1) BROOKS, DAWN ALISA (2) WARSWAWSKY, ALAN M. (3) MONTROSE-RAFEZADEH, CHAHRZAD (4) REIFEL-MILLER, ANNE, (5) PRIETO, LOURDES (6) ROJO, ISABEL (7) MARTIN, JOSE ALFREDO (8) GONZALES GARCIA, MARIA ROSARIO (9) TORRADO, ALICIA (10) FERRITTO CRESPO, RAFAEL (11)
International Info
Classification: C07C 59/68
Publication Number: WO02/100813A2-19.12.2002
Application Date: 2002-05-30
Priority Information
60/297,144 U.S.A 2001-06-07